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Pracinostat inhibits HDACs
InChiKey: DXDRHHKMWQZJHT-FPYGCLRLSA-N
is the most potent and selective Lysine Specific Demethylase-1 (LSD1) inhibitor reported to date
Smiles: CN1C=C(C=N1)C1N=CN(CCC2C=NN(C)C=2)C=1C1=CC=C(C=C1)C#N
63(13):7211-7225
Erastin xicillin Sodium Pracinostat inhibits HDACsErastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i. e. HRAS, KRAS). Erastin produces non apoptotic tumor cell death by altering mitochondrial voltage dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death. Erastin blocks and reverses mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized
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